Compile Data Set for Download or QSAR

Found 161 hits of ic50 data for polymerid = 50006459   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6957 (6,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3ncccc3c21 Show InChI InChI=1S/C15H10N2/c1-2-6-13-11(4-1)15-10-5-3-9-16-12(10)7-8-14(15)17-13/h1-9,17H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.97E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6944 (4-methoxy-13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}...) Show SMILES COc1ccc2ccc3[nH]c4c(cccc4c3c2c1)-c1ccccc1 Show InChI InChI=1S/C23H17NO/c1-25-17-12-10-16-11-13-21-22(20(16)14-17)19-9-5-8-18(23(19)24-21)15-6-3-2-4-7-15/h2-14,24H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.09E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6949 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES c1ccc(cc1)-c1cccc2c1[nH]c1ccc3ccccc3c21 Show InChI InChI=1S/C22H15N/c1-2-7-15(8-3-1)18-11-6-12-19-21-17-10-5-4-9-16(17)13-14-20(21)23-22(18)19/h1-14,23H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.41E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6954 (3,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3cccnc3c21 Show InChI InChI=1S/C15H10N2/c1-2-6-12-11(5-1)14-13(17-12)8-7-10-4-3-9-16-15(10)14/h1-9,17H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.42E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6958 (4-oxido-4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...) Show SMILES [O-][n+]1ccc2ccc3[nH]c4ccccc4c3c2c1 Show InChI InChI=1S/C15H10N2O/c18-17-8-7-10-5-6-14-15(12(10)9-17)11-3-1-2-4-13(11)16-14/h1-9,16H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.05E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Homo sapiens (Human))	BDBM50303035 (4-(4-(5-methylthiophen-2-yl)pyrimidin-2-ylamino)be...) Show SMILES Cc1ccc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1 Show InChI InChI=1S/C15H14N4O2S2/c1-10-2-7-14(22-10)13-8-9-17-15(19-13)18-11-3-5-12(6-4-11)23(16,20)21/h2-9H,1H3,(H2,16,20,21)(H,17,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response				J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV
					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Homo sapiens (Human))	BDBM50303036 (CHEMBL569986 | N-((1-(4-(naphthalen-2-yl)pyrimidin...) Show SMILES CC(=O)NCC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C22H24N4O/c1-16(27)24-15-17-9-12-26(13-10-17)22-23-11-8-21(25-22)20-7-6-18-4-2-3-5-19(18)14-20/h2-8,11,14,17H,9-10,12-13,15H2,1H3,(H,24,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response				J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV
					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Homo sapiens (Human))	BDBM50303037 ((1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-...) Show SMILES NCC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C20H22N4/c21-14-15-8-11-24(12-9-15)20-22-10-7-19(23-20)18-6-5-16-3-1-2-4-17(16)13-18/h1-7,10,13,15H,8-9,11-12,14,21H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	630	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response				J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV
					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Homo sapiens (Human))	BDBM50303038 (1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-a...) Show SMILES NC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1 Show InChI InChI=1S/C19H20N4/c20-17-8-11-23(12-9-17)19-21-10-7-18(22-19)16-6-5-14-3-1-2-4-15(14)13-16/h1-7,10,13,17H,8-9,11-12,20H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response				J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV
					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Homo sapiens (Human))	BDBM50303039 (4-(4-(naphthalen-2-yl)pyrimidin-2-ylamino)benzenes...) Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C20H16N4O2S/c21-27(25,26)18-9-7-17(8-10-18)23-20-22-12-11-19(24-20)16-6-5-14-3-1-2-4-15(14)13-16/h1-13H,(H2,21,25,26)(H,22,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response				J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV
					More data for this Ligand-Target Pair
Dickkopf-related protein 1 (Homo sapiens (Human))	BDBM50303040 (4-(methyl(4-(5-methylthiophen-2-yl)pyrimidin-2-yl)...) Show SMILES CN(c1ccc(cc1)S(N)(=O)=O)c1nccc(n1)-c1ccc(C)s1 Show InChI InChI=1S/C16H16N4O2S2/c1-11-3-8-15(23-11)14-9-10-18-16(19-14)20(2)12-4-6-13(7-5-12)24(17,21)22/h3-10H,1-2H3,(H2,17,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Dkk1-mediated Wnt/beta-catenin signaling in osteosasrcoma cells assessed as potentiation of TCF-luciferase response				J Med Chem 52: 6962-5 (2009) Article DOI: 10.1021/jm9014197 BindingDB Entry DOI: 10.7270/Q2HM58JV
					More data for this Ligand-Target Pair

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